11 Sep

Dr. Karen Alt from Monash University Australia visited Wyss and Joshi Lab

Dr. Karen Alt visited Wyss Institute and delivered a talk “Theranostic Nanoparticles: Opportunities and Challenges”. Dr. Alt also met with Joshi lab members, Bom, Franziska, Ila, Dr. Suastegui, and Mengyuan (Koch Institute, MIT). Prof. Joshi and Dr. Guo had meeting with Dr. Alt afterwards and discussed the possible collaborations.

Dr. Karen Alt is currently a Senior Scientist in the Nanobiotechnology laboratory at Monash University in Melbourne, Australia. The central objective of her research is to develop imaging probes to better understand the underlying mechanisms of different disease processes and the impact of therapy. Dr. Alt and her research group led by Prof. Christoph Hagemeyer are working closely with Prof. Frank Caruso, the Australian Laureate Fellow in The University of Melbourne, on the designs of new nanomedicine and bio-imaging technologies.


From Left to Right: Dr. Junling Guo, Dr. Karen Alt, Prof. Neel Joshi.

23 Aug

New paper on autonomous systems for mercury sequestration published


Congrats to Richie and Peter on the publication of their manuscript “A Synthetic Circuit for Mercury Bioremediation Using Self-Assembling Functional Amyloids” in ACS Synthetic Biology! The paper describes our progress in repurposing biofilms as living programmable materials. The focus on the paper is on demonstrating a self-regulating engineered microbial system that produces an extracellular matrix material for binding to mercury ions in the environment. The self-regulation is important for longevity so that the cells can switch “on” matrix production when mercury levels are high, and switch it “off” when they are low, enabling it to survive in environments where mercury levels fluctuate. This work has potential applications in bioremediation.

Check out a highlight of our work on the Wyss website.

23 Aug

New paper on catalytic biofilms published

Nussbaumer 2017 TOCNussbaumer 2017 TOCPrint

Congrats to Martin, Peter, Richie, and Zsofia on the publication of their manuscript “Bootstrapped biocatalysis: biofilm derived materials as reversibly functionalizable multi-enzyme surfaces” in ChemCatChem! The paper describes our progress on developing catalytic biofilm-based materials that can streamline biotransformation processes. The material we report can immobilize multiple enzymes simultaneously, without the need for expensive purifications or chemical modifications. This allows it to recapitulate multi-step cellular processes outside the cell. The work has potential applications in the manufacture of biofuels, specialty chemicals (vitamins, fragrances, sweeteners, etc.), and pharmaceuticals.

Check out a highlight of our work on the Wyss website.